Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26110%2F26%3A0187741" target="_blank" >RIV/00216305:26110/26:0187741 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s11356-024-32110-w#Fun" target="_blank" >https://link.springer.com/article/10.1007/s11356-024-32110-w#Fun</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-024-32110-w" target="_blank" >10.1007/s11356-024-32110-w</a>

Result language

angličtina

Original language name

Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions

Original language description

Wastewater-based epidemiology (WBE) has been already proposed by several authors for estimating the consumption of drugs, mainly the illicit ones. However, not much information is available about the actual reliability of this tool given the absence of comparison with the actual consumption. This work aims to evaluate the reliability of the WBE as a tool for estimating the consumption of pharmaceuticals in urban area. Measured consumption back-calculated with a WBE approach was compared with prescription of pharmaceutical products as “control.” Moreover, seasonal influence on (i) pharmaceutical consumption, (ii) load of pharmaceutical products in the sewer system, and (iii) reliability of WBE was evaluated. Ciprofloxacin, sulfamethoxazole, metoprolol, carbamazepine, and citalopram were estimated by WBE with a difference respect to the “control” value lower than 0.2 order of magnitude while only trimethoprim and sotalol exceeded the 0.5 order of magnitude of difference but below the 1 order of magnitude. Sedatives were the best represented by WBE (on average 0.15 order of magnitude of difference compared to prescription data). However, further studies are suggested to fully estimate the influence of the type of APs on the reliability of the WBE. Seasonal patterns were found for the load of ciprofloxacin in the sewer and for the consumption of sulfamethoxazole and trimethoprim by population but seasonal changes did not have a significant impact (p > 0.05) on the reliability of WBE. Despite some gaps remained to optimize the reliability of the tool, WBE can be considered a valid method to estimate the consumption of prescribed drugs from the analysis of the sewer system.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

ISSN

0944-1344

e-ISSN

1614-7499

Volume of the periodical

31

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

16426-16436

UT code for WoS article

001157774000009

EID of the result in the Scopus database

2-s2.0-85184257058