Finite element simulation of mechanical tests of individual cells.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F09%3APU83928" target="_blank" >RIV/00216305:26210/09:PU83928 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Finite element simulation of mechanical tests of individual cells.
Original language description
The threedimensional finite element (FE) model of eucaryotic cell presented in the paper comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing cytoskeleton. In contrast to the previous models, this tensegrity structure consists of several parts. External and internal parts count 30 struts and 60 cables each and their corresponding nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate the load transmission from the extracellular space via membrane receptors (focal adhesions) to the central part of the cell (nucleus, centrosome); this ability of the model was tested by simulationof some mechanical tests of isolated cells, in particular tension test with micropipettes, indentation test and magnetic tweezer test. Although material properties of compo-nents have been defined as realistic as possible on the base of t
Czech name
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Czech description
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Project
<a href="/en/project/GA106%2F09%2F1732" target="_blank" >GA106/09/1732: MULTISCALE MODELLING OF BEHAVIOUR OF HYPERELASTIC ANISOTROPIC MATERIALS</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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