Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F14%3APU106786" target="_blank" >RIV/00216305:26210/14:PU106786 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1051/epjconf/20146702006" target="_blank" >http://dx.doi.org/10.1051/epjconf/20146702006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1051/epjconf/20146702006" target="_blank" >10.1051/epjconf/20146702006</a>

Result language

angličtina

Original language name

Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Original language description

It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a filter was placed on glass slide and made transparent. The particles on the filter were counted manually and the deposition was calculated afterwards. The results of the methods were compared and both methods proved to be useful.

Czech name

—

Czech description

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Type

D - Article in proceedings

CEP classification

JR - Other machinery industry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

EPJ Web of Conferences

ISBN

978-80-260-5375-0

ISSN

2100-014X

e-ISSN

—

Number of pages

4

Pages from-to

82-85

Publisher name

E D P SCIENCES

Place of publication

FRANCE

Event location

Kutná Hora

Event date

Nov 19, 2013

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000343672100009