Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU116545" target="_blank" >RIV/00216305:26210/15:PU116545 - isvavai.cz</a>

Result on the web

<a href="http://rsif.royalsocietypublishing.org/content/12/113/20150852" target="_blank" >http://rsif.royalsocietypublishing.org/content/12/113/20150852</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rsif.2015.0852" target="_blank" >10.1098/rsif.2015.0852</a>

Result language

angličtina

Original language name

Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index

Original language description

Background. A rupture risk assessment is critical to the clinical treatment of Abdominal Aortic Aneurysm (AAA) patients. The biomechanical AAA rupture risk assessment quantitatively integrates many known AAA rupture risk factors but the variability of risk predictions due to model input uncertainties remains a challenging limitation. Methods. The present study derives a Probabilistic Rupture Risk Index (PRRI). Specifically, the uncertainties in AAA wall thickness and wall strength were considered, and wall stress was predicted with a state-of-the-art deterministic biomechanical model. The discriminative power of PRRI was tested in a diameter-matched cohort of ruptured (n=7) and intact (n=7) AAAs and compared to alternative risk assessment methods. Results. Computed PRRI at 1.5 Mean Arterial Pressure was significantly (p=0.041) higher in ruptured AAAs (20.21(SD14.15%) than in intact AAAs (3.71(SD 5.77)%). PRRI showed a high sensitivity and specificity (discriminative power of 0.837) to discriminate between ruptured and intact AAA cases. The underlying statistical representation of stochastic data of wall thickness, wall strength and Peak Wall Stress (PWS) had only negligible effects on PRRI computations. Conclusion. Uncertainties in AAA wall stress predictions, the wide range of reported wall strength and the stochastic nature of failure motivate a probabilistic rupture risk assessment. Advanced AAA biomechanical modeling paired with a probabilistic rupture index definition as known from engineering risk assessment seems to be superior to a purely deterministic approach.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Royal Society Interface

ISSN

1742-5689

e-ISSN

1742-5662

Volume of the periodical

113

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000367807000016

EID of the result in the Scopus database

2-s2.0-84954141217