Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F16%3APU119595" target="_blank" >RIV/00216305:26210/16:PU119595 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/17:73587037
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.b.33663" target="_blank" >10.1002/jbm.b.33663</a>
Alternative languages
Result language
angličtina
Original language name
Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments
Original language description
Wear testing of total joint replacement (TJR) is mandatory in preclinical testing before implantation of TJR into the human body. Testing is governed by current international standards that recommend bovine serum (BS) as a lubricating fluid to replace synovial fluid (SF). Recently, the use of BS has been criticized because of differences in content, fluid characteristics, and nonhuman origin. As a result, a more realistic lubricant mimicking SF is needed. To define SF composition, we analyzed SF obtained during revisions of total hip and knee arthroplasties and compared it with SF obtained during primary arthroplasties and from patients without TJR. Samples were acquired from 152 patients. We found that the median total protein concentration for all SF was 36.8 mg/mL, which is significantly higher than concentrations currently recommended by the ISO standards. The gama globulin concentration was significantly higher and the phospholipid concentration significantly lower in patients with revision of TJR compared with patients without TJR. No significant difference was found in hyaluronic acid concentration and viscosity among the groups. Our results support the need to improve the definition of a more clinically relevant wear testing lubricant in the ISO standards.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30211 - Orthopaedics
Result continuities
Project
<a href="/en/project/NT14267" target="_blank" >NT14267: The influence of joint fluid composition on formation of lubricating film in THA</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)
ISSN
1552-4973
e-ISSN
1552-4981
Volume of the periodical
105
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1422-1431
UT code for WoS article
000407055400011
EID of the result in the Scopus database
2-s2.0-84963603091