Simulation of airway deposition distribution of an aerosol drug in COPD patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU130334" target="_blank" >RIV/00216305:26210/18:PU130334 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Simulation of airway deposition distribution of an aerosol drug in COPD patients
Original language description
Medical aerosols are key elements of current chronic obstructive pulmonary disease (COPD) therapy. Therapeutic effects are conditioned by the delivery of the right amount of medication to the right place within the airways, that is, to the drug receptors. Deposition of the inhaled drugs is sensitive to the breathing pattern of the patients which is also connected with the patient’s disease severity. The objective of this work was to measure the realistic inhalation profiles of mild, moderate and severe COPD patients, simulate the deposition patterns of Symbicort® Turbuhaler® dry powder drug and compare them to similar patterns of healthy control subjects. For this purpose a stochastic airway deposition model was applied. Our results revealed that the mount of drug depositing within the lungs correlates with the degree of disease severity. While drug deposition fraction in the lungs of mild COPD patients compares with that of healthy subjects (28% versus 31%), lung deposition fraction characteristic of
Czech name
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Czech description
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Project
<a href="/en/project/LTC17087" target="_blank" >LTC17087: Lung pathology influence on therapeutic aerosol delivery to the lung</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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