The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU132011" target="_blank" >RIV/00216305:26210/19:PU132011 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/19:00510253 RIV/62156489:43110/19:43915679 RIV/61988987:17310/19:A2002100

Result on the web

<a href="https://www.mdpi.com/journal/molecules/special_issues/Gquadruplex_Microorganisms#published" target="_blank" >https://www.mdpi.com/journal/molecules/special_issues/Gquadruplex_Microorganisms#published</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24091711" target="_blank" >10.3390/molecules24091711</a>

Result language

angličtina

Original language name

The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria

Original language description

The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional relevance has been demonstrated in many genomes, including humans. In this study, we analyzed the presence and locations of G-quadruplex-forming sequences by G4Hunter in all complete bacterial genomes available in the NCBI database. G-quadruplex-forming sequences were identified in all species, however the frequency differed significantly across evolutionary groups. The highest frequency of G-quadruplex forming sequences was detected in the subgroup Deinococcus-Thermus, and the lowest frequency in Thermotogae. G-quadruplex forming sequences are non-randomly distributed and are favored in various evolutionary groups. G-quadruplex-forming sequences are enriched in ncRNA segments followed by mRNAs. Analyses of surrounding sequences showed G-quadruplex-forming sequences around tRNA and regulatory sequences. These data point to the unique and non-random localization of G-quadruplex-forming sequences in bacterial genomes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MOLECULES

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1-13

UT code for WoS article

000469518100070

EID of the result in the Scopus database

2-s2.0-85065646357