A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU139548" target="_blank" >RIV/00216305:26210/21:PU139548 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21220/21:00345360

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S235257382100007X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S235257382100007X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotri.2021.100166" target="_blank" >10.1016/j.biotri.2021.100166</a>

Result language

angličtina

Original language name

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Original language description

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

<a href="/en/project/GA20-00483S" target="_blank" >GA20-00483S: An investigation of synovial fluid viscosupplementation and its impact on friction and lubrication</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotribology

ISSN

2352-5738

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

100166-100166

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85100750132