Microstructure of Selective Laser Melted Titanium Lattices and In Vitro Cell Behaviour

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU142437" target="_blank" >RIV/00216305:26210/21:PU142437 - isvavai.cz</a>

Result on the web

<a href="https://www.confer.cz/metal/2021/4259-microstructure-of-selective-laser-melted-titanium-lattices-and-in-vitro-cell-behaviour" target="_blank" >https://www.confer.cz/metal/2021/4259-microstructure-of-selective-laser-melted-titanium-lattices-and-in-vitro-cell-behaviour</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/metal.2021.4259" target="_blank" >10.37904/metal.2021.4259</a>

Result language

angličtina

Original language name

Microstructure of Selective Laser Melted Titanium Lattices and In Vitro Cell Behaviour

Original language description

Selective laser melting (SLM) is a metal additive manufacturing technology that allows the fabrication of complex near-net-shape titanium parts. Among possible applications, titanium is important for the biomedical sector, in particular for orthopaedics due to its low elastic modulus, biocompatibility, high mechanical strength and corrosion resistance. Several studies show the structural properties and mechanical behaviour of titanium lattices that in parallel exhibited the porosity, mechanical strength and elastic modulus of trabecular bone. However, less attention has been devoted to study the biological response to titanium parts fabricated by SLM. Therefore, this work aimed to fabricate commercially pure titanium lattices by SLM and study the behaviour of bone-forming cells cultured on the lattices. The results show that Saos-2 osteoblast-like cells proliferated and covered the entire available surface of the titanium lattices becoming confluent and quiescent. The activity of alkaline phosphatase and the production of extracellular calcium deposits confirmed the growth of viable and mature osteoblasts. The cytocompatibility of the titanium lattices is an additional advantage that adds to the possibility to mimic the porosity and mechanical properties of bone by computer-aided design and subsequently implement the lattice fabrication by SLM, fitting the requirements of individual patients and, consequently, offering a broad range of new bone repair alternatives in orthopaedics. Keywords: selective laser melting, titanium, microstructure, osteoblast, cytocompatibility.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/GA19-22662S" target="_blank" >GA19-22662S: In situ precipitation of hydroxyapatite inside hierarchical titanium structures: a new concept to attain composites without undesirable phases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings 30th Anniversary International Conference on Metallurgy and Materials

ISBN

978-80-87294-99-4

ISSN

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e-ISSN

—

Number of pages

6

Pages from-to

1179-1185

Publisher name

Tanger

Place of publication

neuveden

Event location

Brno

Event date

May 26, 2021

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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