Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU146717" target="_blank" >RIV/00216305:26210/22:PU146717 - isvavai.cz</a>
Result on the web
<a href="https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html" target="_blank" >https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1051/epjconf/202429901029" target="_blank" >10.1051/epjconf/202429901029</a>

Result language
angličtina
Original language name
Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer
Original language description
Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-20357S" target="_blank" >GA22-20357S: Measurement and computational simulation of transport of fibrous aerosols in high velocity gradient flow and interaction of fibres with a wall</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the International Conference Experimental Fluid Mechanics 2022
ISBN
—
ISSN
2101-6275
e-ISSN
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Number of pages
4
Pages from-to
„“-„“
Publisher name
EDP Sciences
Place of publication
Dvůr Králové nad Labem
Event location
Dvůr Králové nad Labem
Event date
Nov 29, 2022
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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