In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F23%3APU147252" target="_blank" >RIV/00216305:26210/23:PU147252 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10455430 RIV/70883521:28610/23:63566558

Result on the web

<a href="https://www.mdpi.com/2075-4442/11/1/12" target="_blank" >https://www.mdpi.com/2075-4442/11/1/12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/lubricants11010012" target="_blank" >10.3390/lubricants11010012</a>

Result language

angličtina

Original language name

In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Original language description

Degradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20301 - Mechanical engineering

Project

<a href="/en/project/GA20-00483S" target="_blank" >GA20-00483S: An investigation of synovial fluid viscosupplementation and its impact on friction and lubrication</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lubricants

ISSN

2075-4442

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

„“-„“

UT code for WoS article

000915175500001

EID of the result in the Scopus database

2-s2.0-85146757532