Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F24%3APU150699" target="_blank" >RIV/00216305:26210/24:PU150699 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0010482524000787?dgcid=author#GS3" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010482524000787?dgcid=author#GS3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.compbiomed.2024.107994" target="_blank" >10.1016/j.compbiomed.2024.107994</a>
Alternative languages
Result language
angličtina
Original language name
Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract
Original language description
The numerical simulation of inhaled aerosols in medical research starts to play a crucial role in understanding local deposition within the respiratory tract, a feat often unattainable experimentally. Research on children is particularly challenging due to the limited availability of in vivo data and the inherent morphological intricacies. CFD solvers based on Finite Volume Methods (FVM) have been widely employed to solve the flow field in such studies. Recently, Lattice Boltzmann Methods (LBM), a mesoscopic approach, have gained prominence, especially for their scalability on High-Performance Computers. This study endeavours to compare the effectiveness of LBM and FVM in simulating particulate flows within a child’s respiratory tract, supporting research related to particle deposition and medication delivery using LBM. Considering a 5-year-old child’s airway model at a steady inspiratory flow, the results are compared with in vitro experiments. Notably, both LBM and FVM exhibit favourable agreement with experimental data for the mean velocity field and the turbulence intensity. For particle deposition, both numerical methods yield comparable results, aligning well with in vitro experiments across a particle size range of 0.1–20 µm. Discrepancies are identified in the upper airways and trachea, indicating a lower deposition fraction than in the experiment. Nonetheless, both LBM and FVM offer invaluable insights into particle behaviour for different sizes, which are not easily achievable experimentally. In terms of practical implications, the findings of this study hold significance for respiratory medicine and drug delivery systems — potential health impacts, targeted drug delivery strategies or optimisation of respiratory therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20300 - Mechanical engineering
Result continuities
Project
<a href="/en/project/GA20-27653S" target="_blank" >GA20-27653S: Influence of infants and children lungs development on flow field and aerosol deposition– computational modelling and experimental validation</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
COMPUTERS IN BIOLOGY AND MEDICINE
ISSN
0010-4825
e-ISSN
1879-0534
Volume of the periodical
170
Issue of the periodical within the volume
107994
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
„“-„“
UT code for WoS article
001179282000001
EID of the result in the Scopus database
2-s2.0-85183975977