In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F24%3APU151083" target="_blank" >RIV/00216305:26210/24:PU151083 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/24:00080560 RIV/00216224:14110/24:00139738
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0169260724000129" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169260724000129</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cmpb.2024.108016" target="_blank" >10.1016/j.cmpb.2024.108016</a>
Alternative languages
Result language
angličtina
Original language name
In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs
Original language description
Background and objectives: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. Methods: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. Results: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of areaaveraged TAWSS related to the old flow waveform is much more pronounced (2.5 divided by 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. Conclusions: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/GA21-21935S" target="_blank" >GA21-21935S: Computational modelling of pulsatile flow in compliant tubes with application for tandem carotid stenosis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
ISSN
0169-2607
e-ISSN
1872-7565
Volume of the periodical
245
Issue of the periodical within the volume
2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
„108016-1“-„108016-10“
UT code for WoS article
001166225300001
EID of the result in the Scopus database
2-s2.0-85183468867