Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F25%3APU156191" target="_blank" >RIV/00216305:26210/25:PU156191 - isvavai.cz</a>

Result on the web

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0316719" target="_blank" >10.1371/journal.pone.0316719</a>

Result language

angličtina

Original language name

Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Original language description

Background and objective The use of bone allograft reconstructions after tumor resection can introduce significant complications. Stable fixation is required to decrease the incidence of mechanical complications of segmental bone allografts. The purpose of the present study is to compare plating fixation methods of diaphyseal allografts after intercalary resection of the femur. Methods We created four defined fixation models using plates and/or intramedullary polymethylmethacrylate (PMMA) to simulate typical bone tumor resection with intercalary allograft reconstruction. One angularly stable plate (DFP) with 13 locking screws and fresh frozen allografts (labeled "I") were used for bone reconstruction. Three modified reconstructions were created: "II" included a supplementary plate (SP) with four locking screws, "III" was augmented with intramedullary PMMA in the allograft, and "IV" combined intramedullary PMMA and both plates. We applied a load model that simulates partial weight bearing on the lower limb to simulate the load during postoperative rehabilitation. Results The highest stress in the DFP occurred at the allograft-bone transition, with variant IV reaching 297 MPa. PMMA augmentation reduced median interfragmentary motion (IFM) and sliding distances, with variant III achieving the lowest distal sliding distance (0.9 mu m) in the distal area. Supplementary plate fixation reduced maximal and median proximal IFM distances (86.9 mu m in variant II vs. 116.0 mu m in variant I) but increased sliding distances (23.7 mu m in variant II vs. 0.6 mu m in variant I). Conclusions PMMA augmentation reduces IFM and sliding distances, enhancing rigidity, particularly in the distal area. Supplementary plate fixation decreases IFM distances in the proximal area but increases sliding distances in the same region. Variants III and IV demonstrate lower IFM and sliding distances in the distal area overall. Variant III shows very low sliding distances in both distal and proximal

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10700 - Other natural sciences

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLOS ONE

ISSN

1932-6203

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

20

Pages from-to

„“-„“

UT code for WoS article

001435274300064

EID of the result in the Scopus database

2-s2.0-85217027243