A New Approach to Define Dynamics of the Ion Channel Gates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F04%3APU39383" target="_blank" >RIV/00216305:26220/04:PU39383 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A New Approach to Define Dynamics of the Ion Channel Gates

Original language description

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable cellmembranes. How these channels respond to changes in the potential across themembrane has been a challenging problem, and different approaches have been proposed to address the mechanism of voltage sensing and gating in these channels. In this study, we attempt a new approach by considering a simple two-state gate system and applying the path probability method to construct a nnonequilibrium statistical mechanical model of the system. The model which is based on the principles of statistical physics provides a firm physical basis for ion channel gating.

Czech name

Nový přístup k definování dynamiky bran iontových kanálů

Czech description

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable cellmembranes. How these channels respond to changes in the potential across themembrane has been a challenging problem, and different approaches have been proposed to address the mechanism of voltage sensing and gating in these channels. In this study, we attempt a new approach by considering a simple two-state gate system and applying the path probability method to construct a noonequilibrium statistical mechanical model of the system. The model which is based on the principles of statistical physics provides a firm physical basis for ion channel gating.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JD - Use of computers, robotics and its application

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroreport

ISSN

0959-4965

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

335-338

UT code for WoS article

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EID of the result in the Scopus database

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