Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F08%3APU77883" target="_blank" >RIV/00216305:26220/08:PU77883 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

Original language description

There have been published several papers on voltammetric ultra-trace determination of some nucleic bases in the presence of Cu(II) using a mercury electrode or solid amalgam electrodes. Carbon electrodes can be used for the same purposes. The aim of thiswork was to employ the behaviour of purines in the presence of Cu(II) to determine these metal ions. Primarily we aimed on investigation of basic electrochemical behaviour of detection copper at hanging mercury drop and carbon paste electrodes by usingof cyclic and differential pulse voltammetry. Thanks to formation of the complex adenine-Cu(II) under the specific conditions the peak of this complex was measured at -0.6 V. The detection limit (3 S/N) for Cu(II) ions was estimated as 5 nM. By using ofthis approach we were able to determine the content of copper in animal tissues even at tens of nM. Moreover we utilized suggested approach to monitor the level of copper ions in samples of blood serum of patients with metabolic disorder.

Czech name

Návrh elektrochemického sensoru pro mikroanalýzu mědi v biologických vzorcích

Czech description

There have been published several papers on voltammetric ultra-trace determination of some nucleic bases in the presence of Cu(II) using a mercury electrode or solid amalgam electrodes. Carbon electrodes can be used for the same purposes. The aim of thiswork was to employ the behaviour of purines in the presence of Cu(II) to determine these metal ions. Primarily we aimed on investigation of basic electrochemical behaviour of detection copper at hanging mercury drop and carbon paste electrodes by usingof cyclic and differential pulse voltammetry. Thanks to formation of the complex adenine-Cu(II) under the specific conditions the peak of this complex was measured at -0.6 V. The detection limit (3 S/N) for Cu(II) ions was estimated as 5 nM. By using ofthis approach we were able to determine the content of copper in animal tissues even at tens of nM. Moreover we utilized suggested approach to monitor the level of copper ions in samples of blood serum of patients with metabolic disorder.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

<a href="/en/project/KAN208130801" target="_blank" >KAN208130801: New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Seventh IEEE Conference on SENSORS

ISSN

1930-0395

e-ISSN

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Volume of the periodical

2008

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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