Spectral and electrochemical analysis of miR-34a-5p

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU117267" target="_blank" >RIV/00216305:26220/15:PU117267 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Spectral and electrochemical analysis of miR-34a-5p
Original language description
MicroRNAs (miRNAs) are small (22 nt), single-stranded, non-coding RNAs known as regulators of gene expression at the mRNA level. Their impact on the final translation product is significant, therefore it is suitable to study them as biomarkers of variousdiseases namely diabetes, cardiovascular, neurodegenerative, viral diseases and cancer [1]. Our attention was aimed at the research of miR-34a-5p related to head and neck cancer (HNC) and also prostate cancer (PCa) where we obtained significant differences in miR-34a-5p expression status between health controls and patients with PCa. This miRNA, belonging to the miR-34 family is directly linked to p53 and Wnt pathways [2]. The tight connection between loss of tumor suppressor function and activation ofoncogenic signaling has been proven for this miRNA. Beside the classical molecular?biological methods studying miRNAs, such as PCR, Northern Blotting (NB), microarrays technologies, new biophysical approaches were applied [3]. The result
Czech name
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Czech description
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Project
<a href="/en/project/ED2.1.00%2F03.0072" target="_blank" >ED2.1.00/03.0072: Centre of sensor, information and communication systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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