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Advanced DNA fingerprint genotyping based on a model developed from real chip electrophoresis data

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU131157" target="_blank" >RIV/00216305:26220/19:PU131157 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/19:00070876 RIV/00216224:14110/19:00110574

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S2090123219300050" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2090123219300050</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jare.2019.01.005" target="_blank" >10.1016/j.jare.2019.01.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Advanced DNA fingerprint genotyping based on a model developed from real chip electrophoresis data

  • Original language description

    Large-scale comparative studies of DNA fingerprints prefer automated chip capillary electrophoresis over conventional gel planar electrophoresis due to the higher precision of the digitalization process. However, the determination of band sizes is still limited by the device resolution and sizing accuracy. Band matching, therefore, remains the key step in DNA fingerprint analysis. Most current methods evaluate only the pairwise similarity of the samples, using heuristically determined constant thresholds to evaluate the maximum allowed band size deviation; unfortunately, that approach significantly reduces the ability to distinguish between closely related samples. This study presents a new approach based on global multiple alignments of bands of all samples, with an adaptive threshold derived from the detailed migration analysis of a large number of real samples. The proposed approach allows the accurate automated analysis of DNA fingerprint similarities for extensive epidemiological studies of bacterial strains, thereby helping to prevent the spread of dangerous microbial infections.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Result continuities

  • Project

    <a href="/en/project/GA17-01821S" target="_blank" >GA17-01821S: High throughput bacterial genome assembly and annotation techniques using genomic signal processing</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Advanced Research

  • ISSN

    2090-1232

  • e-ISSN

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    18

  • Country of publishing house

    EG - EGYPT

  • Number of pages

    10

  • Pages from-to

    9-18

  • UT code for WoS article

    000471218900002

  • EID of the result in the Scopus database

    2-s2.0-85061153550