The Effect of Bio-Conditioning of Titanium Implants for Enhancing Osteogenic Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU140918" target="_blank" >RIV/00216305:26220/19:PU140918 - isvavai.cz</a>
Result on the web
<a href="https://meridian.allenpress.com/joi/article-abstract/45/3/187/365042/The-Effect-of-Bio-Conditioning-of-Titanium?redirectedFrom=fulltext" target="_blank" >https://meridian.allenpress.com/joi/article-abstract/45/3/187/365042/The-Effect-of-Bio-Conditioning-of-Titanium?redirectedFrom=fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1563/aaid-joi-D-18-00020" target="_blank" >10.1563/aaid-joi-D-18-00020</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Bio-Conditioning of Titanium Implants for Enhancing Osteogenic Activity
Original language description
Early and effective integration of titanium-based materials into bone tissue is of vital importance for long-term stability of implants. Surface modification is commonly used to enhance cell-substrate interactions for improving cell adhesion, proliferation, and activity. Here, the surface of titanium substrates and commercial implants were coated with blood (TiB), fetal bovine serum (TiF), and phosphate-buffered saline (TiP) solution using a spin coating process. Surface roughness and wettability of samples were measured using contact angle measurements and atomic force microscopy. The samples were then exposed to human osteoblast-like MG63 cells in order to evaluate adhesion, growth, differentiation, and morphology on the surface of modified samples. Untreated titanium disks were used as controls. The lowest roughness and wettability values were found in unmodified titanium samples followed by TiP, TiF, and TiB. The percentage of cellular attachment and proliferation for each sample was measured using an MTT (3-[4,5-dimethylthiazol-2yl] 2,5diphenyl-2H-tetrazoliumbromide) assay. Cell adhesion and proliferation were most improved on TiB followed closely by TiF. The results of this study revealed an increased expression of the osteogenic marker protein alkaline phosphatase on TiB and the coated commercial titanium implants. These results suggested that precoating titanium samples with blood may improve cellular response by successfully mimicking a physiological environment that could be beneficial for clinical implant procedures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of oral implantology
ISSN
0160-6972
e-ISSN
1548-1336
Volume of the periodical
45
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
187-195
UT code for WoS article
000473116900004
EID of the result in the Scopus database
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