Experimental model of occluded biliary metal stent recanalization using irreversible electroporation via a tubular catheter

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU140769" target="_blank" >RIV/00216305:26220/21:PU140769 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/21:00074435 RIV/65269705:_____/21:00074435 RIV/00216224:14110/21:00120088

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/02656736.2021.1875061" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/02656736.2021.1875061</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/02656736.2021.1875061" target="_blank" >10.1080/02656736.2021.1875061</a>

Result language

angličtina

Original language name

Experimental model of occluded biliary metal stent recanalization using irreversible electroporation via a tubular catheter

Original language description

Purpose To demonstrate the feasibility of irreversible electroporation (IRE) for treating biliary metal stent occlusion in an experimental liver model. Methods and materials IRE was performed using an expandable tubular IRE-catheter placed in nitinol stents in the porcine liver. A 3-electrode IRE-catheter was connected to an IRE-generator and one hundred 100 mu s pulses of constant voltage (300, 650, 1000, and 1300 V) were applied. Stent occlusion was simulated by insertion of liver tissue both ex vivo (n = 94) and in vivo in 3 pigs (n = 14). Three scenarios of the relationship between the stent, electrodes, and inserted tissue (double contact, single contact, and stent mesh contact) were studied. Electric current was measured and resistance and power calculated. Pigs were sacrificed 72 h post-procedure. Harvested samples (14 experimental, 13 controls) underwent histopathological analysis. Results IRE application was feasible at 300 and 650 V for the single and double contact setup in both ex vivo and in vivo studies. Significant differences in calculated resistance between double contact and single contact settings were observed (ex-vivo p < 0.0001, in-vivo p = 0.02; Mann-Whitney). A mild temperature increase of the surrounding liver parenchyma was noted with increasing voltage (0.9-5.9 degrees C for 300-1000 V). The extent of necrotic changes in experimental samples in vivo correlated with the measured electric current (r (2) = 0.39, p = 0.01). No complications were observed during or after the in-vivo procedure. Conclusion Endoluminal IRE using an expandable tubular catheter in simulated metal stent occlusion is feasible. The relationship of active catheter electrodes to stent ingrowth tissue can be estimated based on resistance values.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Hyperthermia

ISSN

0265-6736

e-ISSN

1464-5157

Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

393-401

UT code for WoS article

000626288000001

EID of the result in the Scopus database

2-s2.0-85102198823