Patient-Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULM (TM) during V/A-C and PSV Ventilation Mode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU141503" target="_blank" >RIV/00216305:26220/21:PU141503 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2076-3417/11/9/3745" target="_blank" >https://www.mdpi.com/2076-3417/11/9/3745</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app11093745" target="_blank" >10.3390/app11093745</a>

Result language

angličtina

Original language name

Patient-Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULM (TM) during V/A-C and PSV Ventilation Mode

Original language description

During mechanical ventilation, a disparity between flow, pressure and volume demands of the patient and the assistance delivered by the mechanical ventilator often occurs. This paper introduces an alternative approach of simulating and evaluating patient-ventilator interactions with high fidelity using the electromechanical lung simulator xPULM (TM). The xPULM (TM) approximates respiratory activities of a patient during alternating phases of spontaneous breathing and apnea intervals while connected to a mechanical ventilator. Focusing on different triggering events, volume assist-control (V/A-C) and pressure support ventilation (PSV) modes were chosen to test patient-ventilator interactions. In V/A-C mode, a double-triggering was detected every third breathing cycle, leading to an asynchrony index of 16.67%, which is classified as severe. This asynchrony causes a significant increase of peak inspiratory pressure (7.96 +/- 6.38 vs. 11.09 +/- 0.49 cmH(2)O, p < 0.01)) and peak expiratory flow (-25.57 +/- 8.93 vs. 32.90 +/- 0.54 L/min, p < 0.01) when compared to synchronous phases of the breathing simulation. Additionally, events of premature cycling were observed during PSV mode. In this mode, the peak delivered volume during simulated spontaneous breathing phases increased significantly (917.09 +/- 45.74 vs. 468.40 +/- 31.79 mL, p < 0.01) compared to apnea phases. Various dynamic clinical situations can be approximated using this approach and thereby could help to identify undesired patient-ventilation interactions in the future. Rapidly manufactured ventilator systems could also be tested using this approach.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10700 - Other natural sciences

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Sciences - Basel

ISSN

2076-3417

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000649874100001

EID of the result in the Scopus database

2-s2.0-85105239422