Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142087" target="_blank" >RIV/00216305:26220/21:PU142087 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00124164
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.1c03363" target="_blank" >10.1021/acsomega.1c03363</a>
Alternative languages
Result language
angličtina
Original language name
Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting
Original language description
Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS OMEGA
ISSN
2470-1343
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
43
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
28699-28709
UT code for WoS article
000714105800025
EID of the result in the Scopus database
2-s2.0-85118969345