Heart rate and age modulate retinal pulsatile patterns

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU144892" target="_blank" >RIV/00216305:26220/22:PU144892 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s42003-022-03441-6" target="_blank" >https://www.nature.com/articles/s42003-022-03441-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-022-03441-6" target="_blank" >10.1038/s42003-022-03441-6</a>

Result language
angličtina
Original language name
Heart rate and age modulate retinal pulsatile patterns
Original language description
Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project
<a href="/en/project/GA21-18578S" target="_blank" >GA21-18578S: Dual-wavelength functional retinal imaging and simultaneous biosignals acquisition for ocular blood circulation assessment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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