Corticosteroid Treatment Prediction using Chest X-ray and Clinical Data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F24%3APU149728" target="_blank" >RIV/00216305:26220/24:PU149728 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2001037023004713" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2001037023004713</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.csbj.2023.11.057" target="_blank" >10.1016/j.csbj.2023.11.057</a>

Result language

angličtina

Original language name

Corticosteroid Treatment Prediction using Chest X-ray and Clinical Data

Original language description

Background and Objective: Severe courses of COVID-19 disease can lead to long-term complications. The post-acute phase of COVID-19 refers to the persistent or new symptoms. This problem is becoming more relevant with the increasing number of patients who have contracted COVID-19 and the emergence of new virus variants. In this case, preventive treatment with corticosteroids can be applied. However, not everyone benefits from the treatment, moreover, it can have severe side effects. Currently, no study would analyze who benefits from the treatment. Methods: This work introduces a novel approach to the recommendation of Corticosteroid (CS) treatment for patients in the post-acute phase. We have used a novel combination of clinical data, including blood tests, spirometry, and X-ray images from 273 patients. These are very challenging to collect, especially from patients in the post-acute phase of COVID-19. To our knowledge, no similar dataset exists in the literature. Moreover, we have proposed a unique methodology that combines machine learning and deep learning models based on Vision Transformer (ViT) and InceptionNet, preprocessing techniques, and pretraining strategies to deal with the specific characteristics of our data. Results: The experiments have proved that combining clinical data with CXR images achieves 8% higher accuracy than independent analysis of CXR images. The proposed method reached 80.0% accuracy (78.7% balanced accuracy) and a ROC-AUC of 0.89. Conclusions: The introduced system for CS treatment prediction using our neural network and learning algorithm is unique in this field of research. Here, we have shown the efficiency of using mixed data and proved it on real-world data. The paper also introduces the factors that could be used to predict long-term complications. Additionally, this system was deployed to the hospital environment as a recommendation tool, which admits the clinical application of the proposed methodology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20601 - Medical engineering

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Computational and Structural Biotechnology Journal

ISSN

2001-0370

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

December 24

Country of publishing house

SE - SWEDEN

Number of pages

13

Pages from-to

53-65

UT code for WoS article

001407169500001

EID of the result in the Scopus database

2-s2.0-85179759544