Transurethral ultrasound therapy of the prostate in the presence of calcifications: a simulation study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F18%3APU130744" target="_blank" >RIV/00216305:26230/18:PU130744 - isvavai.cz</a>
Result on the web
<a href="https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/mp.13183" target="_blank" >https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/mp.13183</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mp.13183" target="_blank" >10.1002/mp.13183</a>
Alternative languages
Result language
angličtina
Original language name
Transurethral ultrasound therapy of the prostate in the presence of calcifications: a simulation study
Original language description
Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localised treatment of prostate cancer. One of the limiting factors of this application are the prostatic calcifications which attenuate and reflect ultrasound, and thus, reduce the efficacy of the heating. The aim of this study is find out how prostatic calcifications affect the therapeutic efficacy and what is the best sonication strategy to overcome these limitations. The presence of calcifications in front of the ultrasound field was found to increase the peak pressure by 100% on average while the maximum temperature only rose by 9% during a 20-second sonication. Losses in ultrasound energy were caused due to relative large acoustic impedance mismatch between the prostate tissue and the calcifications (1.63 vs. 3.20 MRayl) and high attenuation coefficient (0.78 vs. 2.64 dB/MHz^1.1/cm), which together left untreated tissue regions behind the calcifications. In addition, elevated temperatures were seen in the region between the transducer and the calcifications. Lower sonication frequencies (1-4 MHz) were not able to penetrate through the calcifications effectively, but longer sonication durations (20-60 s) with selected transducer elements were effective in treating the tissue regions behind the calcifications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/LQ1602" target="_blank" >LQ1602: IT4Innovations excellence in science</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MEDICAL PHYSICS
ISSN
0094-2405
e-ISSN
2473-4209
Volume of the periodical
45
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
4793-4804
UT code for WoS article
000449995900017
EID of the result in the Scopus database
2-s2.0-85054195737