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SoluProtMutDB: A manually curated database of protein solubility changes upon mutations

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F22%3APU146770" target="_blank" >RIV/00216305:26230/22:PU146770 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/22:00130114 RIV/00159816:_____/22:00078809

  • Result on the web

    <a href="https://reader.elsevier.com/reader/sd/pii/S2001037022005025?token=47A572AECBA6EE5C334462194E5EFC9034D184A71EC41EC7B29311B976C644C5FCFBB5B1B449E84DD1A99A04BCFA8708&originRegion=eu-west-1&originCreation=20230110080940" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S2001037022005025?token=47A572AECBA6EE5C334462194E5EFC9034D184A71EC41EC7B29311B976C644C5FCFBB5B1B449E84DD1A99A04BCFA8708&originRegion=eu-west-1&originCreation=20230110080940</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.csbj.2022.11.009" target="_blank" >10.1016/j.csbj.2022.11.009</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    SoluProtMutDB: A manually curated database of protein solubility changes upon mutations

  • Original language description

    Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human diseases with protein aggregation. However, we have limited understanding of the protein structural determinants of solubility, and the available data have mostly been scattered in the literature. Here, we present SoluProtMutDB  the first database containing data on protein solubility changes upon mutations. Our database accommodates 33 000 measurements of 17 000 protein variants in 103 different proteins. The database can serve as an essential source of information for the researchers designing improved protein variants or those developing machine learning tools to predict the effects of mutations on solubility. The database comprises all the previously published solubility datasets and thousands of new data points from recent publications, including deep mutational scanning experiments. Moreover, it features many available experimental conditions known to affect protein solubility. The datasets have been manually curated with substantial corrections, improving suitability for machine learning applications. The database is available at loschmidt.chemi.muni.cz/soluprotmutdb.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Computational and Structural Biotechnology Journal

  • ISSN

    2001-0370

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    SE - SWEDEN

  • Number of pages

    9

  • Pages from-to

    6339-6347

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85142188313