An alternative DSC approach to study hydration of hyaluronan

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F10%3APU87671" target="_blank" >RIV/00216305:26310/10:PU87671 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
An alternative DSC approach to study hydration of hyaluronan
Original language description
Differential scanning calorimetry (DSC) was used to determine the number of water molecules in the hydration shell of hyaluronan of different molecular weights and counterions. First, traditional experiments including freezing/thawing of free water in semi-diluted solutions were carried out leading to the determination of melting enthalpy of freezable water. Non-freezing water was determined using extrapolation to zero enthalpy. For sodium hyaluronan within the molecular weight range between 100 and 740kDa the hydration shell was determined as 0.74 g g(-1) HYA. A larger hydration shell containing 0.84 and 0.82 g g(-1) HYA was determined for hyaluronan of 1390 kDa in its sodium and protonized form, respectively. Second, melting enthalpy of freezing water was further studied applying water vaporation experiments. Resulted plot of enthalpy vs concentration indicated an additional heat volution process which occurs at specific concentration and decreases the measured evaporation enthalpy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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