Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F12%3APU99098" target="_blank" >RIV/00216305:26310/12:PU99098 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater
Original language description
Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in a biological system (e.g. living organism) resulting in enantiomers of these compounds showing different biological properties such as toxicity. For better understanding of the fate of chiral pharmaceuticals in the environment it is of great importance to develop chiral analytical methods capable of trace analysis in the environmental matrices. Enantioselective HPLC-DAD method was developed for the analysis of two non-steroidal anti-inflammatory drugs: ibuprofen and ketoprofen. Enantiomers of these compounds were separated using Chiralpak AD as a chiral column in the normal phase mode. Extracted samples of raw and treated wastewater were at first analysed by achiralHPLC-ESI-MS method, which was used for quantification of the sum of ibuprofen and ketoprofen enantiomers. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is n
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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