CYTOTOXIC AND GENOTOXIC EFFECTS OF PHA/LIPOSOME PARTICLES WITH ENCAPSULATED EXTRACTS FROM COFFEA ARABICA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU130896" target="_blank" >RIV/00216305:26310/18:PU130896 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
CYTOTOXIC AND GENOTOXIC EFFECTS OF PHA/LIPOSOME PARTICLES WITH ENCAPSULATED EXTRACTS FROM COFFEA ARABICA
Original language description
Plants are sources of broad spectrum of compounds potentially useable as antioxidants and UV protectants in cosmetics. This work aims at extraction and preservation of chosen plant extracts into combined PHA/phospholipid nanoparticles to prolong their activity and stability. Extracts were characterized in terms of polyphenols, flavonoids, antioxidant activity, UV protective properties and packed into liposomes. Encapsulation efficiency of PHA/liposomes was characterized by spectrophotometry. Particle size and size distribution were observed by dynamic light scattering and colloid stability by determining zeta-potential. Safety of prepared particles with plant extracts were tested by MTT and LDH assay on human keratinocytes. Influence of functionalized particles on cell viability was evaluated. Genotoxicity was tested using SOS ChromotestTM. All the prepared samples showed moderate or high encapsulation efficiency (40–97 %). Extracted active compounds had high antioxidant activity as well as UV protect
Czech name
—
Czech description
—

Project
<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)