In Vitro Characterization of Poly(Lactic Acid)/Poly(Hydroxybutyrate)/Thermoplastic Starch Blends for Tissue Engineering Application
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU144047" target="_blank" >RIV/00216305:26310/21:PU144047 - isvavai.cz</a>
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000693646800001" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000693646800001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/09636897211021003" target="_blank" >10.1177/09636897211021003</a>
Alternative languages
Result language
angličtina
Original language name
In Vitro Characterization of Poly(Lactic Acid)/Poly(Hydroxybutyrate)/Thermoplastic Starch Blends for Tissue Engineering Application
Original language description
Complex in vitro characterization of a blended material based on Poly(Lactic Acid), Poly(Hydroxybutyrate), and Thermoplastic Starch (PLA/PHB/TPS) was performed in order to evaluate its potential for application in the field of tissue engineering. We focused on the biological behavior of the material as well as its mechanical and morphological properties. We also focused on the potential of the blend to be processed by the 3D printer which would allow the fabrication of the custom-made scaffold. Several blends recipes were prepared and characterized. This material was then studied in the context of scaffold fabrication. Scaffold porosity, wettability, and cell-scaffold interaction were evaluated as well. MTT test and the direct contact cytotoxicity test were applied in order to evaluate the toxic potential of the blended material. Biocompatibility studies were performed on the human chondrocytes. According to our results, we assume that material had no toxic effect on the cell culture and therefore could be considered as biocompatible. Moreover, PLA/PHB/TPS blend is applicable for 3D printing. Printed scaffolds had highly porous morphology and were able to absorb water as well. In addition, cells could adhere and proliferate on the scaffold surface. We conclude that this blend has potential for scaffold engineering.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELL TRANSPLANTATION
ISSN
0963-6897
e-ISSN
1555-3892
Volume of the periodical
30
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000693646800001
EID of the result in the Scopus database
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