Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F23%3APU147396" target="_blank" >RIV/00216305:26310/23:PU147396 - isvavai.cz</a>

Alternative codes found

RIV/68081731:_____/23:00571764

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0378517323001151" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517323001151</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2023.122695" target="_blank" >10.1016/j.ijpharm.2023.122695</a>

Result language

angličtina

Original language name

Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs

Original language description

This contribution is focused on the preparation of a liposomal drug delivery system of erlotinib resisting the nebulization process that could be used for local treatment of non-small-cell lung cancer. Liposomes with different compositions were formulated to reveal their influence on the encapsulation efficiency of erlotinib. An encapsulation efficiency higher than 98 % was achieved for all vesicles containing phosphatidic acid (d ≈ 100 nm , ζ = – 43 mV) even in the presence of polyethylene glycol (d ≈ 150 nm, ζ = – 17 mV) which decreased this value in all other formulas. The three most promising formulations were nebulized by two air-jet and two vibrating mesh nebulizers, and the aerosol deposition in lungs was calculated by tools of computational fluid and particle mechanics. According to the numerical simulations and measurements of liposomal stability, air-jet nebulizers generated larger portion of the aerosol able to penetrate deeper into the lungs, but the delivery is likely to be more efficient when the formulation is administered by Aerogen Solo vibrating mesh nebulizer because of a higher portion of intact vesicles after the nebulization. The leakage of encapsulated drug from liposomes nebulized by this nebulizer was lower than 2 % for all chosen vesicles.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/GA20-27653S" target="_blank" >GA20-27653S: Influence of infants and children lungs development on flow field and aerosol deposition– computational modelling and experimental validation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INTERNATIONAL JOURNAL OF PHARMACEUTICS

ISSN

0378-5173

e-ISSN

1873-3476

Volume of the periodical

634

Issue of the periodical within the volume

march

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000944796400001

EID of the result in the Scopus database

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