Diffusion of sulphonamide antibiotics in agarose hydrogels enriched by humic acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F23%3APU148251" target="_blank" >RIV/00216305:26310/23:PU148251 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0927775723009093?utm_campaign=STMJ_AUTH_SERV_PUBLISHED&utm_medium=email&utm_acid=101843882&SIS_ID=&dgcid=STMJ_AUTH_SERV_PUBLISHED&CMX_ID=&utm_in=DM379129&utm_source=AC_" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927775723009093?utm_campaign=STMJ_AUTH_SERV_PUBLISHED&utm_medium=email&utm_acid=101843882&SIS_ID=&dgcid=STMJ_AUTH_SERV_PUBLISHED&CMX_ID=&utm_in=DM379129&utm_source=AC_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2023.131825" target="_blank" >10.1016/j.colsurfa.2023.131825</a>

Result language

angličtina

Original language name

Diffusion of sulphonamide antibiotics in agarose hydrogels enriched by humic acids

Original language description

Many different pharmaceuticals can evince potentially dangerous behaviour in soil and aqueous environments. Their migration ability and toxicity can be significantly affected by interactions with organic matter. Sulfamethoxazole and sulphapyridine (used as representative commonly used sulphonamide antibiotics) are studied from the point of view of their transport in model hydrogels containing humic substances. Agarose hydrogel was used as a model medium for the transport experiments. Standard Elliot soil humic acid (4S102H) purchased from International Humic Substances Society was incorporated into the hydrogel as an active substance (and representant of organic matter) for interactions with antibiotics and potential suppression of their migration and toxicity in soil systems. Two different experimental arrangements were used: the diffusion from constant source, and the diffusion couple. Diffusion coefficients were determined for pure agarose hydrogels as well as for hydrogels containing humic acids and compared. It was found that the addition of humic acids into hydrogel resulted in the decrease in the effective diffusion coefficient of sulphapyridine and the increase in the effective diffusion coefficient of sulfamethoxazole. Humic acids can suppress the mobility of sulphapyridine and enhance the diffusion of sulfamethoxazole. Batch sorption experiments provided similar adsorption capacities of humic acids for both studied antibiotics. The ratio between adsorption and desorption rate constants were higher than 1 for sulphapyridine and lower than 1 for sulfamethoxazole. It indicated that adsorption predominated for sulphapyridine which resulted in observed lower diffusivity. Desorption experiments showed that a majority of sulphapyridine can be immobilized by interaction with humic acids whereas much more free movable sulfamethoxazole was determined in the comparison with immobilized one.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

ISSN

0927-7757

e-ISSN

1873-4359

Volume of the periodical

673

Issue of the periodical within the volume

131825

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

„“-„“

UT code for WoS article

001054731300001

EID of the result in the Scopus database

2-s2.0-85161348946