Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F23%3APU148520" target="_blank" >RIV/00216305:26310/23:PU148520 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2310-2861/9/5/367" target="_blank" >https://www.mdpi.com/2310-2861/9/5/367</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/gels9050367" target="_blank" >10.3390/gels9050367</a>

Result language

angličtina

Original language name

Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels

Original language description

Transport properties are one of the most crucial assets of hydrogel samples, influencing their main application potential, i.e., as drug carriers. Depending on the type of drug or the application itself, it is very important to be able to control these transport properties in an appropriate manner. This study seeks to modify these properties by adding amphiphiles, specifically lecithin. Through its self-assembly, lecithin modifies the inner structure of the hydrogel, which affects its properties, especially the transport ones. In the proposed paper, these properties are studied mainly using various probes (organic dyes) to effectively simulate drugs in simple release diffusion experiments controlled by UV-Vis spectrophotometry. Scanning electron microscopy was used to help characterize the diffusion systems. The effects of lecithin and its concentrations, as well as the effects of variously charged model drugs, were discussed. Lecithin decreases the values of the diffusion coefficient independently of the dye used and the type of crosslinking. The ability to influence transport properties is better observed in xerogel samples. The results, complementing previously published conclusions, showed that lecithin can alter a hydrogel’s structure and therefore its transport properties.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gels

ISSN

2310-2861

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

„“-„“

UT code for WoS article

001020385500001

EID of the result in the Scopus database

2-s2.0-85160221410