PROFILE COMPARSION OF ZINC-PROTEINS IN CANCER AND CONTROL PROSTATIC CELLS EXPOSED A ZN(II)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F12%3APU126843" target="_blank" >RIV/00216305:26620/12:PU126843 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
PROFILE COMPARSION OF ZINC-PROTEINS IN CANCER AND CONTROL PROSTATIC CELLS EXPOSED A ZN(II)
Original language description
The aim of this study is compare the profile of zinc-proteins level of potential tumour markers in the cell lines PC-3, LNCaP and PNT1A. Zinc plays an important role in the healthy prostatic tissue. It is necessary for the proliferation, differentiation, regulation and apoptosis of the cells. Prostatic healthy tissue accumulate zinc in the cells of the lateral lobes in the prostate. Cancer prostatic tissue loses this ability. Cell lines PC-3 and LNCaP represent prostate cancer and line PNT1A represent healthy and control prostate tissue. We have developed automatic and fast method of the isolation of zinc-proteins from prostatic cells by magnetic particles modified by specific antibody. Zinc was measured by the electrochemical method - differential pulse voltammetry. We determined 15% decreased level of zinc in prostate cancer patients than in the control healthy prostatic cells.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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