ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F12%3APU127016" target="_blank" >RIV/00216305:26620/12:PU127016 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION
Original language description
Doxorubicin is an effective cytostatic drug used for treatment of some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma and/or multiple myeloma. Even though this drug is effective for cancer treatment its toxicity, mainly cardiotoxicity, is limiting the use. For this reason, encapsulation of the drug into the biocarriers, lowering the toxicity, is widely investigated. One of such carriers may be a protein called apoferritin, which is due to the cavity in its structure, able to incept the molecule of interest. Subsequent decrease of pH leads to the opening of the structure and release of the content. The aim of this study is to investigate the behavior of the encapsulated doxorubicin using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).
Czech name
—
Czech description
—

Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)