Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F13%3APU107137" target="_blank" >RIV/00216305:26620/13:PU107137 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes
Original language description
Mini invasive method targeted replacement of tissue defects of articular cartilage and growth plate have been proposed based on our experience in the treatment of bone defects in miniature pigs using new biopolymer composites seeded with Mesenchymal StemCells (MSCs). To study the regeneration of articular cartilage and growth plate, scaffold with self-supporting three-dimensional structures of collagen and chitosan fibers allowing both hydrodynamic casting MSCs and chondrocytes, and good handling, waschosen. These biodegradable scaffolds with seeded cells have successfully undergone preclinical testing on rabbits and minipigs, which were implanted at the site of damage cartilage (knee articular or distal epiphysis). The scaffold initiates tissue regeneration and resorbs in the body with controlled manner.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů