Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F16%3APU119723" target="_blank" >RIV/00216305:26620/16:PU119723 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

Original language description

Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.

Czech name

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Czech description

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Type

A - Audiovisual production

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

978-80-86238-82-1

Place of publication

Neuveden

Publisher/client name

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Version

Neuveden

Carrier ID

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