Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F17%3APU121490" target="_blank" >RIV/00216305:26620/17:PU121490 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1096/fj.201600918R" target="_blank" >http://dx.doi.org/10.1096/fj.201600918R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1096/fj.201600918R" target="_blank" >10.1096/fj.201600918R</a>
Alternative languages
Result language
angličtina
Original language name
Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice
Original language description
Articular cartilage has little regenerative capacity. Recently, genetic lineage tracing experiments have revealed chondrocyte progenitors at the articular surface. We further characterized these progenitors by using in vivo genetic approaches. Histone H2B–green fluorescent protein retention revealed that superficial cells divide more slowly than underlying articular chondrocytes. Clonal genetic tracing combined with immunohistochemistry revealed that superficial cells renew their number by symmetric division, express mesenchymal stem cell markers, and generate chondrocytes via both asymmetric and symmetric differentiation. Quantitative analysis of cellular kinetics, in combination with phosphotungstic acid–enhanced micro–computed tomography,showed that superficial cells generate chondrocytes and contribute to the growth and reshaping of articular cartilage. Furthermore, we found that cartilage renewal occurs as the progeny of superficial cells fully replace fetal chondrocytes during early postnatal life. Thus, superficial cells are self-renewing progenitors that are capable of maintaining their own population and fulfilling criteria of unipotent adult stem cells. Furthermore, the progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal chondrocytes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The FASEB Journal
ISSN
0892-6638
e-ISSN
1530-6860
Volume of the periodical
31
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
1067-1084
UT code for WoS article
000395671200021
EID of the result in the Scopus database
2-s2.0-85014580341