Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130003" target="_blank" >RIV/00216305:26620/18:PU130003 - isvavai.cz</a>

Result on the web

<a href="https://elifesciences.org/articles/40179" target="_blank" >https://elifesciences.org/articles/40179</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.40179" target="_blank" >10.7554/eLife.40179</a>

Result language

angličtina

Original language name

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

Original language description

In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

—

Volume of the periodical

neuveden

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

26

Pages from-to

1-26

UT code for WoS article

000454489700001

EID of the result in the Scopus database

2-s2.0-85059247209