Doxorubicin and ellipticine loaded apoferritin and its effect on cancer and healthy cell lines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU136067" target="_blank" >RIV/00216305:26620/18:PU136067 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/2211-5463.12453" target="_blank" >https://doi.org/10.1002/2211-5463.12453</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Doxorubicin and ellipticine loaded apoferritin and its effect on cancer and healthy cell lines
Original language description
Despite advances in cancer diagnosis and therapy, high-risk neuroblastoma (NBL) remains lethal in about 50% of patients because of aggressive cell growth and chemoresistance. Therefore, new agents are needed to improve its prognosis. Apoferritin is a protein composed of 24 polypeptide subunits, structurally arranged to create an internal cavity, which can be artificially employed for carrying of some molecules of interest. The aim of this study was to compare the cytotoxic effects of doxorubicin (DOX) and ellipticine (ELLI) loaded apoferritin (APODOX resp. APOELLI) and free DOX resp. ELLI on NBL cells UKF-NB-4, chemoresistant sublines derived from this cell line and non-malignant fibroblasts (HDFn) in vitro. We show here that the effect of APODOX on NBL cells is similar to that of free DOX. The cytotoxicity of APOELLI is lower than cytotoxicity of free cytostatic, but APOELLI induces more double strand breaks than free ELLI. Further, using fluorescence microscopy, we have shown that apoferritin can d
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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