Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU141200" target="_blank" >RIV/00216305:26620/21:PU141200 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/21:10428976
Result on the web
<a href="https://www.nature.com/articles/s41598-021-84579-x" target="_blank" >https://www.nature.com/articles/s41598-021-84579-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-021-84579-x" target="_blank" >10.1038/s41598-021-84579-x</a>
Alternative languages
Result language
angličtina
Original language name
Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system
Original language description
Amyloid plaques are small (similar to 50 mu m), highly-dense aggregates of amyloid beta (A beta) protein in brain tissue, supposed to play a key role in pathogenesis of Alzheimer's disease (AD). Plaques' in vivo detection, spatial distribution and quantitative characterization could be an essential marker in diagnostics and evaluation of AD progress. However, current imaging methods in clinics possess substantial limits in sensitivity towards A beta plaques to play a considerable role in AD screening. Contrast enhanced X-ray micro computed tomography (micro CT) is an emerging highly sensitive imaging technique capable of high resolution visualization of rodent brain. In this study we show the absorption based contrast enhanced X-ray micro CT imaging is viable method for detection and 3D analysis of A beta plaques in transgenic rodent models of Alzheimer's disease. Using iodine contrasted brain tissue isolated from the Tg-F344-AD rat model we show the micro CT imaging is capable of precise imaging of A beta plaques, making possible to further analyze various aspects of their 3D spatial distribution and other properties.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000630512600001
EID of the result in the Scopus database
2-s2.0-85102685147