Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU141829" target="_blank" >RIV/00216305:26620/21:PU141829 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/21:00119963
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s10570-021-04104-1.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s10570-021-04104-1.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10570-021-04104-1" target="_blank" >10.1007/s10570-021-04104-1</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model
Original language description
Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/TH04020540" target="_blank" >TH04020540: New bioactive hemostatics and collagen-cellulose wound dressings</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELLULOSE
ISSN
0969-0239
e-ISSN
1572-882X
Volume of the periodical
14
Issue of the periodical within the volume
28
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
9369-9382
UT code for WoS article
000682466900002
EID of the result in the Scopus database
2-s2.0-85112668135