Freeze-drying transparent hydrogel films from natural guma Karaya modified with octenidine dihydrochloride for infected wound healing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142528" target="_blank" >RIV/00216305:26620/21:PU142528 - isvavai.cz</a>
Result on the web
<a href="http://www.interdisciplinarymeeting.cz/2021/shell/sbornik-2021.pdf" target="_blank" >http://www.interdisciplinarymeeting.cz/2021/shell/sbornik-2021.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Freeze-drying transparent hydrogel films from natural guma Karaya modified with octenidine dihydrochloride for infected wound healing
Original language description
Wound healing is a process which requires an appropriate approach for effective and accelerated healing. Variety of materials including natural and synthetic polymers are used for the production of films, gels, hydrogels or sponges. Gum Karaya (GK) is a natural polymer, resin able to form a gel with antimicrobial properties supporting the healing process1. Here, GK was modified with synthetic hydrophilic gelling polymers and emollient component to obtain soft, elastic and transparent film via freeze-drying technique. To increase antimicrobial activity an antiseptic agent octenidine dihydrochloride (OCT) was added due to its antimicrobial effect, low absorption to the skin and no systemic toxicity. OCT is widely used antiseptics for topical wounds (acute, chronic) with antimicrobial effect against Gram-positive and Gram-negative bacteria including resistant pathogens.
Czech name
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Czech description
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Project
<a href="/en/project/NU20-05-00166" target="_blank" >NU20-05-00166: New approaches to infected wound healing using hydrogels from Gum Karaya natural resin modified with innovative components targeted at multidrug resistant bacterial strains</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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