Questions about the role of P3HT nanoparticles in retinal stimulation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU143382" target="_blank" >RIV/00216305:26620/21:PU143382 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41565-021-01044-6" target="_blank" >https://www.nature.com/articles/s41565-021-01044-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41565-021-01044-6" target="_blank" >10.1038/s41565-021-01044-6</a>

Result language
angličtina
Original language name
Questions about the role of P3HT nanoparticles in retinal stimulation
Original language description
Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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