A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU144729" target="_blank" >RIV/00216305:26620/22:PU144729 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3144/expresspolymlett.2022.59" target="_blank" >https://doi.org/10.3144/expresspolymlett.2022.59</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3144/expresspolymlett.2022.59" target="_blank" >10.3144/expresspolymlett.2022.59</a>

Result language

angličtina

Original language name

A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Original language description

In recent times, autologous fat grafting has emerged as one of the most popular techniques for restoring volume depletion. Although the retention predictability of grafted fat has been improved, the quality of grafted tissue is still unsatisfactory. Unpredictable volume loss and low-fat survival is a major problem after application. Biodegradable PLGA-PEGPLGA (poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-pol (lactic-co-glycolic acid)) hydrogel delivery system enriched with stable fibroblast growth factor 2 (FGF2-STAB®), due to its properties, seems to be attractive material that will help to increase fat life. In this study, the mechanism of FGF2-STAB® release from an injectable thermosensitive and biodegradable PLGA-PEG-PLGA hydrogel was monitored. First-order kinetics were controlled mainly by decreasing the concentration of an active compound in the matrix and, at a later stage, by matrix degradation. Furthermore, the activity of the protein after release from the hydrogel matrix was studied. No loss of FGF2-STAB® activity in the dynamic system after 14 days has been detected. The development of such a drug delivery system appears promising for further use in reconstructive medicine e.g., in mixing with fat graft being the subject of current research.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Quality internal grants at BUT</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EXPRESS POLYM LETT

ISSN

1788-618X

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

8

Country of publishing house

HU - HUNGARY

Number of pages

14

Pages from-to

798-811

UT code for WoS article

000812326600003

EID of the result in the Scopus database

—