Microrobots with Antimicrobial Peptide Nanoarchitectonics for the Eradication of Antibiotic-Resistant Biofilms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU145575" target="_blank" >RIV/00216305:26620/22:PU145575 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/22:43921874
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202112935" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202112935</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202112935" target="_blank" >10.1002/adfm.202112935</a>
Alternative languages
Result language
angličtina
Original language name
Microrobots with Antimicrobial Peptide Nanoarchitectonics for the Eradication of Antibiotic-Resistant Biofilms
Original language description
Bacterial biofilms are composed of a consortium of bacteria that communicate with each other through quorum sensing. Therefore, bacteria can form an extracellular matrix, which is a mucus composed of exopolysaccharides, peptidoglycans, and extracellular DNA, through these communication molecules. The matrix protects the community of bacteria from the adverse effects of the external environment, including antibiotics, biocides, and eradicating agents. Self-propelled functional microrobots offer great promises in the biomedical field. The self-propelled microrobots represent an innovative platform in microrobotic research, aiming to have an important role in the biomedical field. One of the potential applications is removal of bacterial biofilms. Herein, the specific design of multifunctional microrobots is demonstrated using antimicrobial-designed peptides for eradication of methicillin-resistant Staphylococcus aureus (MRSA)-produced biofilms. The designed microrobots can perform various tasks, including autonomous navigation toward bacterial cells, mechanical entry into bacterial biofilms, and blockage of the replication of bacterial DNA by indolicidin peptides. The implemented design extends the microrobot applications not only to the removal of biological aggregates but also to the delivery and release of drugs or even target manipulation, demonstrating their great potential for use in biomedical research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials for Optics and Electronics
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
32
Issue of the periodical within the volume
43
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000839921300001
EID of the result in the Scopus database
2-s2.0-85135832830