Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU150048" target="_blank" >RIV/00216305:26620/23:PU150048 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/23:00079651 RIV/61989100:27240/23:10252977

Result on the web

<a href="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556" target="_blank" >https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bios.2023.115113" target="_blank" >10.1016/j.bios.2023.115113</a>

Result language

angličtina

Original language name

Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion

Original language description

This work examines the suitability of graphene-based 3D-printed nanocomposite bioelectronics as innovative systems to in situ monitor and evaluate both breast cancer cell adhesion and the chemosensitivity of anti-cancer drugs. With this aim, 3D-printed nanocomposite graphene electrodes (3D-nGEs) -made of a commercially available graphene/polylactic acid filament- have been covalently biofunctionalized with an extracellular matrix protein (i.e., fibronectin) by exploiting the carbon reactivity of 3D-nGEs. The specificity and selectivity of the developed electrochemical system to monitor breast cancer cell adhesion has been tested via electrochemical impedance spectroscopy (EIS). Importantly, the resulting 3D-printed bioelectronic system displayed excellent accuracy for the rapid screening of anti-cancer drugs, which exactly corresponded with the results achieved by the standard optical method, while having the advantage of employing a label-free approach. In light of the current state-of-the-art in the field, this proof-of-concept connects electronics to biological systems within 3D printing technology, providing the bases for the sustainable and cost-effective manufacturing of graphene-based 3D-printed nanocomposite bioelectronics to simulate in vivo microenvironments using in situ and real time electronic output signals.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOSENSORS & BIOELECTRONICS

ISSN

0956-5663

e-ISSN

1873-4235

Volume of the periodical

226

Issue of the periodical within the volume

115113

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

„“-„“

UT code for WoS article

000933955500001

EID of the result in the Scopus database

2-s2.0-85147603217