Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU150079" target="_blank" >RIV/00216305:26620/23:PU150079 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27240/23:10253613
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.3c09920" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.3c09920</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.3c09920" target="_blank" >10.1021/acsami.3c09920</a>
Alternative languages
Result language
angličtina
Original language name
Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA
Original language description
Quantum dot-based materials have been found to be excellent platforms for biosensing and bioimaging applications. Herein, self-propelled microrobots made of graphene quantum dots (GQD-MRs) have been synthesized and explored as unconventional dynamic biocarriers toward the optical "on-the-fly" monitoring of DNA. As a first demonstration of applicability, GQD-MRs have been first biofunctionalized with a DNA biomarker (i.e., fluorescein amidite-labeled, FAM-L) via hydrophobic pi-stacking interactions and subsequently exposed toward different concentrations of a DNA target. The biomarker-target hybridization process leads to a biomarker release from the GQD-MR surface, resulting in a linear alteration in the fluorescence intensity of the dynamic biocarrier at the nM range (1-100 nM, R-2 = 0.99), also demonstrating excellent selectivity and sensitivity, with a detection limit as low as 0.05 nM. Consequently, the developed dynamic biocarriers, which combine the appealing features of GQDs (e.g., water solubility, fluorescent activity, and supramolecular pi-stacking interactions) with the autonomous mobility of MRs, present themselves as potential autonomous micromachines to be exploited as highly efficient and sensitive "on-the-fly" biosensing systems. This method is general and can be simply customized by tailoring the biomarker anchored to the GQD-MR's surface.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/GX19-26896X" target="_blank" >GX19-26896X: 2D Nanomaterials Electrochemistry</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS applied materials & interfaces
ISSN
1944-8244
e-ISSN
1944-8252
Volume of the periodical
15
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
58548-58555
UT code for WoS article
001128294000001
EID of the result in the Scopus database
2-s2.0-85180066329