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Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU150079" target="_blank" >RIV/00216305:26620/23:PU150079 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989100:27240/23:10253613

  • Result on the web

    <a href="https://pubs.acs.org/doi/10.1021/acsami.3c09920" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.3c09920</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acsami.3c09920" target="_blank" >10.1021/acsami.3c09920</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA

  • Original language description

    Quantum dot-based materials have been found to be excellent platforms for biosensing and bioimaging applications. Herein, self-propelled microrobots made of graphene quantum dots (GQD-MRs) have been synthesized and explored as unconventional dynamic biocarriers toward the optical "on-the-fly" monitoring of DNA. As a first demonstration of applicability, GQD-MRs have been first biofunctionalized with a DNA biomarker (i.e., fluorescein amidite-labeled, FAM-L) via hydrophobic pi-stacking interactions and subsequently exposed toward different concentrations of a DNA target. The biomarker-target hybridization process leads to a biomarker release from the GQD-MR surface, resulting in a linear alteration in the fluorescence intensity of the dynamic biocarrier at the nM range (1-100 nM, R-2 = 0.99), also demonstrating excellent selectivity and sensitivity, with a detection limit as low as 0.05 nM. Consequently, the developed dynamic biocarriers, which combine the appealing features of GQDs (e.g., water solubility, fluorescent activity, and supramolecular pi-stacking interactions) with the autonomous mobility of MRs, present themselves as potential autonomous micromachines to be exploited as highly efficient and sensitive "on-the-fly" biosensing systems. This method is general and can be simply customized by tailoring the biomarker anchored to the GQD-MR's surface.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    21001 - Nano-materials (production and properties)

Result continuities

  • Project

    <a href="/en/project/GX19-26896X" target="_blank" >GX19-26896X: 2D Nanomaterials Electrochemistry</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ACS applied materials & interfaces

  • ISSN

    1944-8244

  • e-ISSN

    1944-8252

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    50

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    58548-58555

  • UT code for WoS article

    001128294000001

  • EID of the result in the Scopus database

    2-s2.0-85180066329