Photo-Chemical Stimulation of Neurons with Organic Semiconductors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU150715" target="_blank" >RIV/00216305:26620/23:PU150715 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/advs.202300473" target="_blank" >10.1002/advs.202300473</a>
Alternative languages
Result language
angličtina
Original language name
Photo-Chemical Stimulation of Neurons with Organic Semiconductors
Original language description
Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Science
ISSN
2198-3844
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
31
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
„“-„“
UT code for WoS article
001057823100001
EID of the result in the Scopus database
2-s2.0-85169437223