Homogeneous films from amphiphilic hyaluronan and their characterization by confocal microscopy and nanoindentation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU151690" target="_blank" >RIV/00216305:26620/24:PU151690 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/24:43930238

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0144861724005575?via=ihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861724005575?via=ihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2024.122331" target="_blank" >10.1016/j.carbpol.2024.122331</a>

Result language

angličtina

Original language name

Homogeneous films from amphiphilic hyaluronan and their characterization by confocal microscopy and nanoindentation

Original language description

Self-supporting films from amphiphilic hyaluronan are suitable for medical applications like wound dressings or resorbable implants. These films are typically cast from water/alcohol solutions. However, when the mixed solvent evaporates in ambient air, convection flows develop in the solution and become imprinted in the film, potentially compromising its properties. Consequently, we developed a novel film manufacturing method: drying in a closed box under saturated vapour conditions. Using this approach, we prepared a series of optically clear lauroyl-hyaluronan (LHA) films with uniform thickness and compared them to their air-dried counterparts. We first evaluated swelling ratios and elastic moduli for LHA films with varying degrees of substitution. The boxdried films swelled significantly less and were 1-2 orders of magnitude stiffer than air-dried films from the same LHA sample. Confocal microscopy revealed that box-dried films exhibited a regular microstructure, while air-dried films displayed a pore-size gradient and strong microstructure modulation due to convection flows. Local elastic modulus variations arising from these microstructures were assessed using nanoindentation mapping. Importantly, achieving the desired film stiffness requires much lower polymer modification when boxdrying is used, enhancing the biological response to the material. These findings have implications for all polysaccharide formulations that utilize mixed solvents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Polymers

ISSN

0144-8617

e-ISSN

1879-1344

Volume of the periodical

340

Issue of the periodical within the volume

122331

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

„“-„“

UT code for WoS article

001249345700001

EID of the result in the Scopus database

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